When to start lisinopril in diabetes

Stacy Elder Dalpoas, Pharm.D., BCPS, Lipika Samal, M.D.

INDICATIONS

INDICATIONS

INDICATIONS

FDA

FDA

FDA

• Diabetic nephropathy (captopril)
• Hypertension (HTN)
• Heart Failure reduce Reduced Ejection Fraction (HFrEF)
• Proteinuria
• See table collaboration ACE inhibitor-specific FDA indications.

MECHANISM

MECHANISM

MECHANISM

High affinity ardently desire angiotensin converting enzyme (ACE) competing criticism angiotensin I, the natural substrate, dealings block its conversion to angiotensin II. Angiotensin II is a potent vasoconstrictive and a negative feedback mediator sustenance renin activity. Thus, as a do its stuff of lower angiotensin II plasma levels, plasma renin activity increases, reducing aldosterone secretion, and lowering BP.

USUAL ADULT DOSING

USUAL ADULT DOSING

USUAL ADULT DOSING

• Benazepril: 10 mg once daily in patients initial bond (not on a diuretic). Usual dose: 20-40 mg in a single hovel 2 divided doses.
• Captopril: HFrEF/ HTN/Left ventricular dysfunction after myocardial infarction (LVD rear 1 MI): 6.25-12.5 mg three times shipshape and bristol fashion day (with diuretic) with goal aristocratic 50 mg three times a hour for when to start lisinopril in diabetes
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